You will hear a conversation between twofriends, one of whom iscomplaining about atelephone booking. Decide if each sentenceiscorrect or incorrect. lf it is correct, tick (/) YES.lf it isincorrect, tick (./) NO.
LinkersLink the sentences. Use the words in brackets in thecorrect tense. (See suggested Answers section)1 The journey ended.We got off the boat. (as soon as)2 The boat was sai l ing. We wereeat ing ice-cream on the deck. (whi le)3 was driving. I heard aloud noise. (when)4 The plane hi t some turbulence. The pi lot madean announcement (after)5 booked my flight. I looked at travelwebsites on the Internet. (as soon as)
Summerhill schoolis not a(n)1) ordinary school.Also known astheonly'freeschool' 2) of itskind in the UK,Summerhill is allaboutfreedom. AtSummerhill lessons are not3) compulsory. lf a pupildoesn't like maths, heor she can choose not to go to classes. Thatofcourse doesn't mean that a pupil can always doas he or she likes.There are 190 rules atSummerhill and one of the first thingsteachers4) instruct children to do is to 5) treat eachother with 6)respect. As a result, pupils are7) well-behaved and 8) value goodmanners.Pupils say that studying at Summerhill can be9) lifechanging.'Learning to 10) rely onourselves to make decisions issomething thatwe wouldn't learn in an ordinary school,'11)commented fourteen-year-old pupil JoWhitley. Parents are alsoenthusiastic.'Summerhill has 12) improved our daughters'mannerssaid one of them.'lt is a great school!'
Radcliffe College. In 1903, she wrote anautobiographical bookcalTed The Snry of my Life.ln1904, Helen graduated from RadcliffeCollege becomingthe first deaf and blind person to graduate fromcollege.Helen became famous all over the world as an authorandspeaker and travelled to over 39 countries withAnne. Anne Sullivandied in 1936. Helen devoted therest of her life to raising fundsfor blind and deafpeople in America. In 1960, she publishedanotherbook, entitled Light in my Darkness. She died in June,1968in Connecticut.Helen Keller will always be remembered asanexceptional person who overcame her blindness anddeafness toachieve great things. As she always said,'The best and mostbeautiful things in the worldcannot be seen or even touched. Thevmust be feltwithin the heart.'32
COURSES on offer: French, ltalian, 2) Spanish,Greek and 3)PortugueseAll our 4) teachers are native speakers with aminimum of4 years' 5) teaching expeTience.Courses start in 6) September andconsist of atotal of 28 lessons.
c include a quotation (i.e. a sentence or phrasetaken from abook, play, etc). When we use aquotation, it is necessary tomention the nameof the person who said/wrote it.As G.K Chestertonsaid, 'Education is simfly the soul ofa society as it passes fromone generation to another'
To sum up, I believe there are more advantages thandisadvantagesto travelllng abroad. After all, if youdon't travel and exposeyourself to different cultures,you will shut yourself off from therest of the world.As St. Augustine said, 'The world is a book,andthose who do not travel read only one page.'
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\"Each species' promoter contains a cAMP/response element (CRE)1 consensus sequence () upstream of a TATA box. Two other members of this family of proteins, chromogranin B and secretogranin II (also known as chromogranin C), contain similar CRE and TATA homologies in their proximal gene promoters (8, 9).\"
Many transcription factors (TFs) may occur upstream and occasionally downstream of the transcription start site (TSS), in this gene's promoter. The following have been examined so far: (1) AGC boxes (GCC boxes), (2) ATA boxes, (3) CAAT boxes, (4) C and D boxes, (5) CArG boxes, (6) CENP-B boxes, (7) CGCG boxes, (8) DREB boxes, (9) EIF4E basal elements (4EBEs), (10) enhancer boxes (E boxes), (11) Factor II B recognition elements, (12) G boxes, (13) GLM boxes, (14) HNF6s, (15) HY boxes, (16) Metal responsive elements (MREs), (17) Motif ten elements (MTEs), (18) STAT5s, (19) TATA boxes, (20) TATCCAC boxes, (21) X boxes and (22) Y boxes.
Regarding hypothesis 1: there are no ATA boxes in the core promoter of A1BG from either direction or strand. This hypothesis has been shown to be true. A corollary hypothesis might be 1.1: there are no ATA boxes in the proximal promoter of A1BG from either direction or strand. This corollary hypothesis may be true. \"The analysis of the promoter region indicated that a putative ATA box is located 54 nucleotides upstream from the transcription start site\". There is one inverse and inverse complement ATA box in the proximal promoter in the positive direction between 4050 and 4300: 3'-AAATAA-5' at 4142, and 3'-TTTATT-5' at 4142. As the TSS is at 4300 nts, this ATA box is some 158 nts away, where with the smaller data set 3'-TTTATT-5' was at 703. As the TSS is at 858 nts, this ATA box is some 155 nts away, which is approximately the same number of nts from the TSS but not close enough to be in the core promoter and not 54 nts upstream from the TSS or to match other such genes with an ATA box.
Gene ID: 7422 VEGFA vascular endothelial growth factor A. \"This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.\"
A1BG does not have a TATA box in the core promoter region. There is the sequence 3'-TGCTATATAGATGGCAACTAAGCACTTGGGGAAAAAA-5' for which the first nt (T) is number 58856598 or 1574 nt upstream from the beginning of the 3'-UTR at 58858172. Unless another variant exists, -1574 nt from the beginning of the 3'-UTR is a large number of nts away from the TSS.
The hypothesis: TATA boxes are not involved in the transcription of A1BG is true. \"In virtually every RNA polymerase II-transcribed gene examined, the sequence TATAAA was present 25 to 30 nts upstream of the transcription start site.\"
\"Several transcription factors have been implicated in glucose-mediated expression of genes involved in diabetic nephropathy. This review focuses on the transcription factors upstream stimulatory factors 1 and 2 (USF1 and 2), activator protein 1 (AP-1), nuclear factor (NF)-κB, cAMP-response-element-binding protein (CREB), nuclear factor of activated T cells (NFAT), and stimulating protein 1 (Sp1). In response to high glucose, several of these transcription factors regulate the gene encoding the profibrotic cytokine transforming growth factor β, as well as genes for a range of other proteins implicated in inflammation and extracellular matrix turnover, including thrombospondin 1, the chemokine CCL2, osteopontin, fibronectin, decorin, plasminogen activator inhibitor 1 and aldose reductase.\" 153554b96e